JNU-0921, as a CD137 activator, exhibits highly efficient oral activity. It enhances the mRNA expression of IFN-gamma and GZMB and induces luciferase activity with an EC50 of 64.07 nM. JNU-0921 also boosts both the efficacy and memory function of cytotoxic CD8+ T cells (CTL), alleviating their exhaustion. Moreover, it promotes the polarization of helper T cells towards a Type 1 helper profile, thereby augmenting their activity to enhance CTL function. Additionally, JNU-0921 possesses anticancer properties.
Molecular Weight:
316.31
Formula:
C19H12N2O3
Target:
TNF
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