BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
Molecular Weight:
287.74
Purity:
99.34%
CAS Number:
[4929-23-1]
Formula:
C15H14ClN3O
Target:
Lipoxygenase
T9108
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