MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinsons disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
Molecular Weight:
297.13
Purity:
99.49%
CAS Number:
[36913-39-0]
Formula:
C12H12IN
Target:
Mitochondrial Metabolism|||Autophagy
T9169
T9169
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