(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.
Molecular Weight:
419.3
Purity:
99.68%
CAS Number:
[694522-87-7]
Formula:
C17H15BrN4O2S
Target:
Casein Kinase
T9356
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