BC-LI-0186, CAS [[695207-56-8]]

Product Overview

• Article Name: BC-LI-0186, CAS [[695207-56-8]]
• Biozol Catalog Number: TGM-T9533
• Supplier Catalog Number: T9533
• Alternative Catalog Number: TGM-T9533-1MLX10MM(INDMSO), TGM-T9533-1MG, TGM-T9533-2MG, TGM-T9533-5MG, TGM-T9533-10MG, TGM-T9533-25MG, TGM-T9533-50MG, TGM-T9533-100MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide

Product Description

BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) with IC50 of 46.11 nM. BC-LI-0186 competitively binds the RagD interaction site of LRS with Kd of 42.1 nM and has no effect on LRS-vps34, LRS-eprs, RagB-RagD association, mTORC1 complex formation. BC-LI-0186 potently inhibits the activity of tumor-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 can be used for lung cancer-related research.

Product Properties

• Molecular Weight: 429.53
• Purity: 0.9971
• CAS Number: [695207-56-8]
• Formula: C22H27N3O4S
• Target: Others