NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) that binds with high affinity to heteromeric alpha3beta4 and alpha4beta2 nAChRs, displaying beta-subunit preference and no activation at alpha4-containing receptors. The maximal efficacy of NS3861 depends on the ligand-binding domain, and a serine to threonine substitution in the principal subunit may explain the lack of activation at alpha4-containing receptors.
Molecular Weight:
284.22
Purity:
0.9985
CAS Number:
[216853-59-7]
Formula:
C12H14BrNS
Target:
AChR
T9542
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