(Z)-Orantinib ((Z)-SU6668) is an effective, selective, orally active, ATP-competitive inhibitor of Flk-1/KDR, PDGFRbeta, and FGFR1 with IC50 values of 2.1, 0.008, and 1.2 µM, respectively. As a potent anti-angiogenic and anti-tumor compound, (Z)-Orantinib ((Z)-SU6668) induces significant regression in established tumors. (Z)-Orantinib serves as a valuable tool for investigating tumor angiogenesis inhibition mechanisms, tumor microenvironment regulation, and targeted anti-cancer strategy development, providing highly reliable experimental support for exploring solid tumor drug mechanisms and drug screening.
Molecular Weight:
310.35
Purity:
98.05%
CAS Number:
[210644-62-5]
Formula:
C18H18N2O3
Target:
PDGFR|||VEGFR|||FGFR
T9684
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