Debio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. Debio-0123 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. Debio-0123 increases the antitumoral activity of Carboplatin in vivo whereas neither agent was active alone [1].
Molecular Weight:
511.45
Purity:
0.9993
CAS Number:
[2243882-74-6]
Formula:
C26H28Cl2N6O
Target:
CDK|||Wee1
T9864
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