MAb604.107 is a human monoclonal antibody targeting NOTCH1. It inhibits the proliferation of primary T-ALL cells and reduces CD34/CD44 expression. MAb604.107 demonstrates antitumor activity in four tumor xenograft mouse models: MDA-MB-231, HCC-1806, BT-474, and HCT-116. It can be utilized in research on T acute lymphoblastic leukemia (T-ALL).
Target:
Gamma-secretase
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