RO5323441 is a humanized monoclonal antibody specifically targeting the human placenta growth factor (PlGF). The compound binds to PlGF, blocking its interaction with the receptor VEGFR-1 (Flt-1) and thereby inhibiting downstream signaling. In experimental studies, RO5323441 is utilized to inhibit angiogenic pathways, block PlGF-induced receptor phosphorylation, and suppress tumor growth.
Target:
VEGFR
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