IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML).
Target:
Apoptosis|||Caspase
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