DMA4-H228 is an ionizable cationic lipidoid employed in creating lipid nanoparticles (LNPs) for mRNA delivery in vivo. These LNPs, enriched with DMA4-H228, specifically accumulate in antigen-presenting cells within the mouse spleen. When encapsulating mRNA for ovalbumin, these LNPs activate splenic antigen-presenting cells and elevate serum IFN-alpha levels in mice. Additionally, in a B16/F10-OVA murine melanoma model, such LNPs reduce tumor volume, increase intratumoral CD8+ T cells, and elevate serum anti-ovalbumin IgG titers.
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