Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid beta-oligomers (SO-Abeta) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimers disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
Molecular Weight:
248.36
CAS Number:
[550-90-3]
Formula:
C15H24N2O
Target:
Potassium Channel|||AChR|||Beta Amyloid
TMA0805
TMA0805
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