Irinotecan-d10 Hydrochloride, CAS [[718612-62-5]] Preis auf Anfrage
Biozol Catalog Number:
TGM-TMID-0078
Supplier Catalog Number:
TMID-0078
Alternative Catalog Number:
TGM-TMID-0078-1MG,TGM-TMID-0078-5MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Irinotecan-d10 Hydrochloride is a deuterated compound of Irinotecan Hydrochloride. Irinotecan Hydrochloride has a CAS number of 100286-90-6. Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.
Molecular Weight:
633.2
CAS Number:
[718612-62-5]
Formula:
C33H29D10ClN4O6
Target:
Topoisomerase|||Autophagy
TMID-0078
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