Etoposide-13C,d3 is a form of etoposide that is labeled with 13C and deuterium. Etoposide (VP-16, VP-16-213) is a widely used antitumor chemotherapeutic agent. It functions by inhibiting topoisomerase II, thereby hindering DNA replication. Additionally, etoposide induces cell cycle arrest, apoptosis, and autophagy.