Sulindac-d3 is a deuterated compound of Sulindac. Sulindac has a CAS number of 38194-50-2. Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway, this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.
Molecular Weight:
359.43
Formula:
C20H14D3FO3S
TMIJ-0274
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