ZNRF3 Protein, Human, Recombinant (His & SUMO)

Product Overview

• Article Name: ZNRF3 Protein, Human, Recombinant (His & SUMO)
• Biozol Catalog Number: TGM-TMPH-01274
• Supplier Catalog Number: TMPH-01274
• Alternative Catalog Number: TGM-TMPH-01274-1MG,TGM-TMPH-01274-5UG,TGM-TMPH-01274-10UG,TGM-TMPH-01274-20UG,TGM-TMPH-01274-50UG,TGM-TMPH-01274-100UG,TGM-TMPH-01274-200UG,TGM-TMPH-01274-500UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: RING-type E3 ubiquitin transferase ZNRF3 , RING finger protein 203 , KIAA1133 , Zinc/RING finger protein 3 , E3 ubiquitin-protein ligase ZNRF3 , ZNRF3 , RNF203

Product Description

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.

Images

TMPH-01274