Sodium channel protein brain I subunit alpha , SCN1A , SCN1 , NAC1 , Voltage-gated sodium channel subunit alpha Nav1.1 , Sodium channel protein type I subunit alpha , Sodium channel protein type 1 subunit alpha
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.
TMPH-02118
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