NR3B1 , ESRL1 , Nuclear receptor subfamily 3 group B member 1 , ERR1 , Steroid hormone receptor ERR1 , Estrogen receptor-like 1 , Estrogen-related receptor alpha (ERR-alpha) , ESRRA
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5-TNAAGGTCA-3. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
TMPH-02142
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