JAK-binding protein (JAB) , STAT-induced STAT inhibitor 1 (SSI-1) , Tec-interacting protein 3 (TIP-3) , SOCS-1 , TIP3 , SOCS1 , SSI1 , Suppressor of cytokine signaling 1
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
TMPH-02156
* VAT and and shipping costs not included. Errors and price changes excepted
