Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 , TGF-beta-activated kinase 1-binding protein 2 , TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 , MAP3K7IP2 , KIAA0733 , TAK1-binding protein 2 (TAB-2) , TAB2
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of Lys-63-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to Lys-63-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.
TMPH-02194
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