TGS1 Protein, Human, Recombinant (His & SUMO)

Product Overview

• Article Name: TGS1 Protein, Human, Recombinant (His & SUMO)
• Biozol Catalog Number: TGM-TMPH-02246
• Supplier Catalog Number: TMPH-02246
• Alternative Catalog Number: TGM-TMPH-02246-1MG,TGM-TMPH-02246-5UG,TGM-TMPH-02246-10UG,TGM-TMPH-02246-20UG,TGM-TMPH-02246-50UG,TGM-TMPH-02246-100UG,TGM-TMPH-02246-200UG,TGM-TMPH-02246-500UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: PIMT , Trimethylguanosine synthase , NCOA6IP , Hepatocellular carcinoma-associated antigen 137 , CLL-associated antigen KW-2 , PRIP-interacting protein with methyltransferase motif (PIMT,PIPMT) , Cap-specific guanine-N(2) methyltransferase , HCA137 , TGS1 , Nuclear receptor coactivator 6-interacting protein

Product Description

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Images

TMPH-02246