GLI , Oncogene GLI , Zinc finger protein GLI1 , GLI1 , Glioma-associated oncogene
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5-GACCACCCA-3. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling., Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
Molecular Weight:
23.3 kDa (predicted)
TMPH-02321
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