Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5-3 exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3 flap. Also has endonuclease activity toward 5-flaps.
Molecular Weight:
21.4 kDa (predicted)
TMPH-02649
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