Connexin-43 (Cx43) , Gap junction alpha-1 protein , Cxn-43 , Gap junction 43 kDa heart protein , Gja1
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles., Connexin 43 is possibly the ATP-induced pore of mouse macrophages.
TMPH-02669
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