M-myrmeciitoxin-Mp2b , Pilosin-3 subunit b (Pilosulin-3b) , DELTA-myrtoxin-Mp1a B chain (Mp1a B chain) , M-MIITX-Mp2b
Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles. Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells,. Shows broad-spectrum activity against a diverse range of bacteria, and cell lines, as well as hemolytic activity (EC(50)=2.18 uM). In vivo, shows moderate insecticidal activity against D.melanogaster and potent anthelmintic activity against the veterinary nematode H.contortus. In addition, intraplantar injection into mice induces nocifensive behavior and mechanical allodynia.
TMPH-03035
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