Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)

Product Overview

• Article Name: Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)
• Biozol Catalog Number: TGM-TMPH-03037
• Supplier Catalog Number: TMPH-03037
• Alternative Catalog Number: TGM-TMPH-03037-1MG,TGM-TMPH-03037-5UG,TGM-TMPH-03037-10UG,TGM-TMPH-03037-20UG,TGM-TMPH-03037-50UG,TGM-TMPH-03037-100UG,TGM-TMPH-03037-200UG,TGM-TMPH-03037-500UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: Alpha-CbT , Alpha-elapitoxin-Nk2a (Alpha-EPTX-Nk2a) , Alpha-Cbtx , Long neurotoxin 1 , Alpha-CT , Alpha-cobratoxin , Siamensis 3 , Alpha-Ctx

Product Description

Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA)., Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC(50)=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC(50)=1370 nM). However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs., Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7/CHRNA7 nAChR and is considerably more active in blocking the alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.

Images

TMPH-03037