Protein with TSP type-1 repeat , RSPO3 , R-spondin-3 , Roof plate-specific spondin-3 , CRISTIN1 , THSD2 , Thrombospondin type-1 domain-containing protein 2 , PWTSR
R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases, and one TSP type-1 domain, RSPO3 founctions as a activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Otherwise, RSPO3 may negatively regulate the TGF-beta pathway.
Molecular Weight:
61 KDa (reducing condition)
TMPJ-00163
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