Transforming Growth Factor beta-1 (TGFbeta-1) is a secreted protein which belongs to the TGF-beta family. TGFbeta-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFbeta-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFbeta-1 peptide. TGFbeta-1 may also form heterodimers with other TGFbeta family members. It has been found that TGFbeta-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Molecular Weight:
12-18 KDa (reducing condition)
Purity:
>99.99%
TMPJ-00249
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