TSR-I , Serine/threonine-protein kinase receptor R3 , ALK-1 , SKR3 , activin A receptor , activin A receptor type II-like 1 , TGF-B superfamily receptor type I , Activin receptor-like kinase 1 , ACVRL1
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.
TMPJ-00304
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