IFN-al , CRF2-1 , IFN-alpha/beta receptor 1 , human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC , alpha-type antiviral protein , AVP , Cytokine receptor family 2 member 1 , IFN-alpha/beta R1 , beta-type antiviral protein , IFN-alpha/beta receptor 1 , IFN-alpha/beta R1 , Cytokine receptor class-II member 1 , beta-type antiviral protein , human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC , alpha-type antiviral protein
Interferon-alpha/beta receptor 1 (IFN- alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
TMPJ-00331
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