c-Kit/CD117 Protein, Human, Recombinant (hFc)

Product Overview

• Article Name: c-Kit/CD117 Protein, Human, Recombinant (hFc)
• Biozol Catalog Number: TGM-TMPJ-00402
• Supplier Catalog Number: TMPJ-00402
• Alternative Catalog Number: TGM-TMPJ-00402-1MG,TGM-TMPJ-00402-5UG,TGM-TMPJ-00402-10UG,TGM-TMPJ-00402-20UG,TGM-TMPJ-00402-50UG,TGM-TMPJ-00402-100UG,TGM-TMPJ-00402-200UG,TGM-TMPJ-00402-500UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog , p145 c-kit , SCFR , Tyrosine-protein kinase Kit , Proto-oncogene c-Kit , Mast/stem cell growth factor receptor Kit , PBT , Piebald trait protein , KIT , CD117

Product Description

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

Images

TMPJ-00402