FcRII-a , IGFR2 , Low Affinity Immunoglobulin Gamma Fc Region Receptor II-a , Fc-Gamma RII-a , FCGR2A1 , Fc-gamma RII-a , FCGR2A , CDw32 , FCG2 , Fc-Gamma-RIIa , CD32 , Low Affinity Immunoglobulin gamma Fc Region Receptor II-a , IgG Fc receptor II-a , Fc-gamma-RIIa
Receptors for the Fc region of IgG (FcgammaR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcgammaRs are divided into three classes designated FcgammaRI (CD64), FcgammaRII (CD32), and FcgammaRIII (CD16), which generate multiple isoforms, are recognized. The activating type receptor either has or associates noncovalently with an accessory subunit that has an immunoreceptor tyrosinebased activation motif (ITAM) in its cytoplasmic domain. FcgammaRI binds IgG with high affinity and functions during early immune responses, whereas FcgammaRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human FcgammaRII (A, B, and C) and one for mouse (FcgammaRIIB), encoding type I transmembrane proteins with ITAM motifs (FcgammaRII A and C) or ITIM motifs (FcgammaRIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a), FcgammaRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRgamma, CD32a (FcgammaRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcgamma RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
TMPJ-00446
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