Leukocyte Immunoglobulin-Like Receptor 2 , Monocyte/Macrophage Immunoglobulin-Like Receptor 10 , MIR-10 , CD85 Antigen-Like Family Member D , Immunoglobulin-Like Transcript 4 , ILT-4 , L , Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 , LIR-2 , CD85d
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
TMPJ-00552
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