BCAS2 , DNA Amplified in Mammary Carcinoma 1 Protein , Pre-mRNA-Splicing Factor SPF27 , Spliceosome-Associated Protein SPF 27 , Breast Carcinoma-Amplified Sequence 2 , DAM1
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator and is capable of enhancing ER-mediated transcription.
TMPJ-00705
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