Neuronal Munc18-1-Interacting Protein 3 , Neuron-Specific X11L2 Protein , Amyloid Beta A4 Precursor Protein-Binding Family A Member 3 , Adapter protein X11gamma , Mint-3 , Adapter protein X11Gamma , Amyloid beta A4 Precursor Protein-Binding Family A Member 3 , MINT3 , APBA3 , X11L2
Amyloid beta A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimers disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-alpha and -beta which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amyloid protein (APP) in vivo and may modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
TMPJ-00722
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