Lipopolysaccharide-associated protein 4 , Cartilage-derived morphogenetic protein 1 , Radotermin , LPS-associated protein 4 , CDMP-1 , LAP-4 , Growth/differentiation factor 5 , Bone morphogenetic protein 14 , GDF-5 , BMP-14 , CDMP1
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFbeta superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.
TMPJ-00966
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