Alpha-1 , Mannoside Acetylglucosaminyltransferase 2 , 6-Mannosyl-Glycoprotein 2-beta-N-Acetylglucosaminyltransferase , NT-II , GlcNAc-T II , 6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase , 2-N-acetylglucosaminyltransferase II , beta-1 , Beta-1 , N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase II , alpha-1
Mannoside Acetylglucosaminyltransferase 2 (MGAT2) is a single-pass type II membrane protein that contains the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain and a C-terminal catalytic domain. MGAT2 catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A.
TMPJ-01092
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