Tumor-Related Protein , 58 kDa Heat Shock Protein , PDRC1 , C1orf10 , Squamous Epithelial Heat Shock Protein 53 , CRNN , 53 kDa Squamous Epithelial-Induced Stress Protein , DRC1 , 53 kDa Putative Calcium-Binding Protein , Cornulin
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When Cornulin is overexpressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.
TMPJ-01372
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