Notch 1 Protein, Mouse, Recombinant (aa 18-526, His)

Product Overview

• Article Name: Notch 1 Protein, Mouse, Recombinant (aa 18-526, His)
• Biozol Catalog Number: TGM-TMPJ-01452
• Supplier Catalog Number: TMPJ-01452
• Alternative Catalog Number: TGM-TMPJ-01452-1MG,TGM-TMPJ-01452-5UG,TGM-TMPJ-01452-10UG,TGM-TMPJ-01452-20UG,TGM-TMPJ-01452-50UG,TGM-TMPJ-01452-100UG,TGM-TMPJ-01452-200UG,TGM-TMPJ-01452-500UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: mT14 , Neurogenic locus notch homolog protein 1 , Motch A , Notch 1

Product Description

Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain and a PEST sequence. Notch1 may play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation and may be involved in mesoderm development, somite formation and neurogenesis.

Images

TMPJ-01452