GABA(A) receptor-associated protein like 1 , ATG8B , ATG8L , APG8L , ATG8 , GEC1 , APG8-LIKE
ATG8, also known as GABARAPL1, is a ubiquitin-like protein that has a crystal structure. ATG8 consists of a 5-stranded beta-sheet, which is enclosed by two alpha-helices at one side and one alpha-helix at the other side and exhibits a conserved GABARAP domain. It functions in the formation of autophagosomal membranes. The transient conjugation of ATG8 to the autophagosomal membrane through a ubiquitin-like conjugation system is essential for autophagy in eukaryotes. Autophagy is induced upon nutrient depletion or rapamycin treatment and leads to the response of more than 30 autophagy-related (ATG) genes known so far, including ATG8.
TMPY-03268
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