Gypsetin inhibits the activity of acyl-CoA:cholesterol acyltransferase (ACAT), showing inhibitory effects on rat liver microsomal ACAT with an IC50 of 18 µM, and competes with oleoyl-CoA substrate, possessing a Ki value of 5.5 µM. Additionally, Gypsetin prevents the formation of cholesterol esters from oleic acid with an IC50 of 0.65 µM.
Molecular Weight:
540.653
CAS Number:
[155114-38-8]
Formula:
C32H36N4O4
Target:
Acyltransferase
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