Meranzin, a bioactive compound derived from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) and isolated from Murraya exotica L. leaves, targets the alpha 2-adrenoceptor and engages the AMPA-ERK1/2-BDNF signaling pathway. It offers promising potential for preventing the comorbidity of atherosclerosis and depression due to its significant anti-inflammatory and analgesic properties.