NIR-BG2 is a near-infrared fluorescent probe that targets senescence-associated beta-galactosidase (SA-beta-Gal). Upon activation by SA-beta-Gal, NIR-BG2 undergoes hydrolysis, releasing an electrophilic methylquinone that covalently binds to surrounding proteins for in situ labeling, enhancing the fluorescence signal 16-fold at 709 nm. NIR-BG2 holds potential for in vivo imaging studies of cellular senescence.
Molecular Weight:
730.81
CAS Number:
[3036456-18-2]
Formula:
C42H46F2NO8
Target:
Others|||glycosidase
TN11369
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