1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cgamma-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. OODBL also exhibits potent antitumor activity against several human cancer cell lines.
