Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-iB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.
Molecular Weight:
316.26
CAS Number:
[56365-38-9]
Formula:
C16H12O7
Target:
IL Receptor|||NF-kappaB|||Bcl-2 Family|||NOS|||VEGFR|||Reactive Oxygen Species|||Prostaglandin Receptor|||STAT|||COX|||JNK|||DNA/RNA Synthesis|||ERK|||MMP|||MAPK|||TLR|||TNF
TN3587
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