Fortunellin is a flavonoid isolated from Fortunella margarita (kumquat) that alleviates histopathological heart injury while improving cardiac function by reducing inflammation and oxidative stress in fructose-induced metabolic disease models. Fortunellin decreases pro-inflammatory cytokines and suppresses phosphorylation of IKKalpha, IkappaBalpha, and NF-kappaB, while upregulating antioxidant defenses including SOD, CAT, HO-1, and activating AMPK/Nrf2 signaling, supporting the use of Fortunellin in research on diabetic cardiomyopathy and cardiometabolic disorders.
Molecular Weight:
592.55
Purity:
98.38%
CAS Number:
[20633-93-6]
Formula:
C28H32O14
Target:
AMPK|||IkappaB/IKK
TN4077
TN4077
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