Tagitinin A is a naturally occurring sesquiterpene lactone compound that acts as a dual agonist of peroxisome proliferator-activated receptor alpha/gamma (PPARalpha/PPARgamma) and exerts antihyperglycemic and antihyperlipidemic effects in diabetes research.Tagitinin A is able to bind directly to the ligand-binding domain of PPARgamma (IC50=55 µM), and also stimulates the PPAR Tagitinin A can directly bind to the PPARgamma ligand binding domain (IC50=55 µM) and also stimulate the PPARalpha-dependent activation of the SULT2A1 gene promoter. As a phytotoxin, Tagitinin A significantly inhibited the growth of wheat germ sheath.
Molecular Weight:
368.42
CAS Number:
[59979-61-2]
Formula:
C19H28O7
Target:
Antifection|||PPAR
TN5091
TN5091
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