NDPIH, derived from Hericium erinaceus (monkey head mushroom), exhibits significant neurotrophic activity. It enhances extensive axonal growth and synaptic branching in cultured hippocampal neurons under serum-free conditions. Although pharmacological inhibition of actin receptor kinase B (TrkB) partially blocks the activity induced by NDPIH, the compound can independently activate the ERK1/2 signaling pathway, bypassing TrkB.
Molecular Weight:
315.41
CAS Number:
[1360168-37-1]
Formula:
C19H25NO3
TN8363
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