Melicopine is an alkaloid found in Z. simulans, known for its antimalarial and anticancer properties. It inhibits P. falciparum strains, including chloroquine-sensitive 3D7 (IC50 of 29.7 µg/mL) and chloroquine-resistant Dd2 (IC50 of 33.7 µg/mL). Additionally, Melicopine exhibits cytotoxicity against prostate cancer cells PC-3M (IC50 of 47.9 µg/mL) and LNCaP (IC50 of 37.8 µg/mL), but it is inactive in non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds potential for research in anticancer and anti-infective applications.
Molecular Weight:
313.31
CAS Number:
[568-01-4]
Formula:
C17H15NO5
Target:
Parasite
TN8420
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